Unnecessary antibiotic use in Asthma exacerbations may increase hospital stay, costs.
Adults with uncontrolled persistent asthma despite maintenance treatment require additional therapy. Since macrolide antibiotics can be used to treat persistent asthma, we aimed to assess the efficacy and safety of oral azithromycin as add-on therapy in patients with uncontrolled persistent asthma on medium-to-high dose inhaled corticosteroids plus a long-acting bronchodilator.
Patients were randomly assigned 1: Patients were centrally allocated using concealed random allocation from a computer-generated random numbers table with permuted blocks of 4 or 6 and stratification for centre and past smoking.
Primary efficacy endpoints were the rate of total severe and moderate asthma exacerbations over 48 weeks and asthma quality of life. Data were analysed on an intention-to-treat basis.
Findings Between June 12,and Jan 31,patients were randomly assigned in the azithromycin group and in the placebo group. Interpretation Adults with persistent symptomatic asthma experience fewer asthma exacerbations and improved quality of life when treated with oral azithromycin for 48 weeks.
Azithromycin might be a useful add-on therapy in persistent asthma.Diflucan official prescribing information for healthcare professionals. Includes: indications, dosage, adverse reactions, pharmacology and more.
The Centers for Disease Control and Prevention estimates that 37% of all antibiotic use in hospitals may be inappropriate, and reducing unnecessary antibiotic prescribing is now considered an urgent national priority. 1,2 In the United States alone, asthma exacerbations led to million emergency department visits and hospitalizations.
Additionally, azithromycin use was associated with improved asthma control (assessed by Asthma Control Questionnaire 6), reduced the number of patients reporting a respiratory tract infection, and lowered the rate of antibiotic courses for respiratory indications.
Unnecessary antibiotic use for asthma exacerbations linked to increased hospital stays, costs "All hospitals should assess their practice in caring for patients hospitalized with asthma and. Natural remedies for asthma include simple but effective home remedies like apple cider vinegar, aloe vera, garlic, and even oregano oil.
was to investigate whether azithromycin has value for patients with persistent asthma in reducing the severity doi: /jabfm Azithromycin for Bronchial Asthma in Adults