A compound of structural Formula I or a salt thereof, wherein:
Top Assignees Patent application title: Disclosed herein are compounds and compositions useful in the treatment of bromodomain-containing protein-mediated diseases, such as cancer, having the structure of Formula I: STR Methods of inhibiting activity of a bromodomain-containing protein in a human or animal subject are also provided.
The compound as recited in claim 1, wherein the compound has structural Formula II: STR or a salt thereof, wherein: The compound as recited in claim 1, wherein the compound has structural Formula III: The compound as recited in claim 3, wherein: X is chosen from imidazole, phenyl, pyridine, and pyrazole.
Y and Z are alkyl. R2 is chosen from alkyl and alkoxy. R4 and R6 are independently chosen from alkoxy, H, halo, and N R3.
A composition comprising a compound of claim 1 and a pharmaceutically acceptable carrier, adjuvant, or vehicle. A method for inhibiting activity of a bromodomain-containing protein, or a mutant thereof, in a biological sample comprising the step of contacting said biological sample with a compound according to claim 1.
The method according to claim 11, wherein the bromodomain-containing protein is TRIM A method for treating a bromodomain-containing protein-mediated disorder in a subject in need thereof, comprising the step of administering to said subject a compound according to claim 1. The method according to claim 13, wherein the subject is a human.
The method according to claim 13, wherein the bromodomain-containing protein is TRIM The method according to claim 13, wherein the bromodomain-containing protein-mediated disorder is a proliferative disorder, inflammatory disease, sepsis, neurological disease, autoimmune disease, or viral infection.
The method according to claim 17, wherein the proliferative disorder is cancer. The method according to claim 18, wherein the cancer is chosen from acute myelogenous leukemia and Burkitt's lymphoma.
The method according to claim 17, wherein the autoimmune and inflammatory diseases involve an inflammatory response to infections with bacteria, viruses, fungi, parasites or their toxins.
The method according to claim 17, wherein the autoimmune and inflammatory diseases or conditions are chosen from sepsis, sepsis syndrome, septic shock, endotoxemia, systemic inflammatory response syndrome SIRSmulti-organ dysfunction syndrome, toxic shock syndrome, acute lung injury, ARDS adult respiratory distress syndromeacute renal failure, fulminant hepatitis, bums, acute pancreatitis, post-surgical syndromes, sarcoidosis, Herxheimer reactions, encephalitis, myelitis, meningitis, malaria and SIRS associated with viral infections such as influenza, herpes zoster, herpes simplex and coronavirus.
The method according to claim 17, wherein the neurological diseases or conditions are chosen from Alzheimer's disease, Parkinson's disease, Huntington disease, bipolar disorder, schizophrenia, Rubinstein-Taybi syndrome, and epilepsy. A method of treating a bromodomain-containing protein-mediated disorder in a subject in need thereof, comprising the sequential or co-administration of a compound of claim 1 or a pharmaceutically acceptable salt thereof, and another therapeutic agent.United States: Charlotte.
(a) Write the balanced equation for the complete combustion of heptane, (b) Write a balanced equation for the incomplete combustion of 1-pentene, Identify each reaction as an addition reaction or a substitution reaction. Isopropyl butyrate is found in alcoholic beverages.
Isopropyl butyrate is present in apricot, kumquat peel oil, American cranberry, papaya, strawberry, spineless monkey orange and sparkling wine.
Isopropyl butyrate is a flavouring ingredient. Apr 08, · Best Answer: isopropanol with butanoic acid under acid catalysis (H2SO4 or HCl) should give isopropyl butanoate (isopropyl butyrate) in a Fischer esterification. Can you confirm 3-chloropentene for us?
That's not standard nomenclature. Dichloromethane (methylene chloride) CH4 + 2 Cl = CH2Cl2 + 2 HClStatus: Resolved. Find the training resources you need for all your activities. Studyres contains millions of educational documents, questions and answers, notes about the course, tutoring questions, cards and course recommendations that will help you learn and learn.
Write an equation for the synthesis of a.
isopropyl butanoate from isopropanol and butanoic acid b. butanoic acid from 1-butanol 5. Classify each of the reactions in problem 4 as an oxidation-reduction, substitution, addition, or esterfication reaction.